Evolutionary Coupling Analysis
Predicted and experimental contacts
Secondary structure from ECs
EC score distribution and threshold
Top ECs
Rank |
Residue 1 |
Amino acid 1 |
Residue 2 |
Amino acid 2 |
EC score |
1 |
842 |
R |
848 |
P |
0.51 |
2 |
818 |
P |
822 |
Q |
0.48 |
3 |
843 |
S |
847 |
Q |
0.48 |
4 |
842 |
R |
846 |
G |
0.46 |
5 |
682 |
G |
686 |
A |
0.45 |
6 |
698 |
A |
702 |
L |
0.45 |
7 |
847 |
Q |
851 |
K |
0.44 |
8 |
693 |
G |
697 |
P |
0.44 |
9 |
677 |
S |
681 |
E |
0.44 |
10 |
691 |
R |
697 |
P |
0.43 |
11 |
682 |
G |
692 |
Q |
0.43 |
12 |
813 |
A |
817 |
Q |
0.43 |
13 |
840 |
R |
844 |
A |
0.42 |
14 |
678 |
Q |
686 |
A |
0.41 |
15 |
667 |
Q |
673 |
T |
0.41 |
16 |
680 |
Q |
684 |
Q |
0.41 |
17 |
684 |
Q |
688 |
A |
0.41 |
18 |
704 |
S |
708 |
S |
0.40 |
19 |
684 |
Q |
692 |
Q |
0.40 |
20 |
692 |
Q |
699 |
G |
0.40 |
21 |
668 |
G |
676 |
G |
0.40 |
22 |
688 |
A |
694 |
R |
0.39 |
23 |
849 |
A |
853 |
Q |
0.39 |
24 |
797 |
A |
801 |
G |
0.39 |
25 |
705 |
E |
709 |
Q |
0.39 |
26 |
804 |
P |
809 |
P |
0.39 |
27 |
694 |
R |
698 |
A |
0.39 |
28 |
846 |
G |
850 |
S |
0.38 |
29 |
669 |
P |
673 |
T |
0.38 |
30 |
674 |
R |
682 |
G |
0.38 |
31 |
670 |
A |
677 |
S |
0.38 |
32 |
838 |
L |
842 |
R |
0.38 |
33 |
812 |
P |
816 |
E |
0.38 |
34 |
808 |
V |
812 |
P |
0.38 |
35 |
805 |
L |
809 |
P |
0.38 |
36 |
701 |
S |
705 |
E |
0.38 |
37 |
838 |
L |
845 |
Q |
0.38 |
38 |
846 |
G |
852 |
E |
0.37 |
39 |
669 |
P |
680 |
Q |
0.37 |
40 |
831 |
R |
835 |
L |
0.37 |
41 |
673 |
T |
684 |
Q |
0.37 |
42 |
669 |
P |
677 |
S |
0.37 |
43 |
705 |
E |
710 |
P |
0.37 |
44 |
814 |
Q |
818 |
P |
0.37 |
45 |
816 |
E |
821 |
E |
0.36 |
46 |
816 |
E |
820 |
R |
0.36 |
47 |
801 |
G |
805 |
L |
0.36 |
48 |
673 |
T |
679 |
R |
0.36 |
49 |
803 |
A |
807 |
P |
0.36 |
50 |
687 |
A |
691 |
R |
0.36 |
51 |
689 |
P |
693 |
G |
0.36 |
52 |
802 |
P |
806 |
Q |
0.36 |
53 |
682 |
G |
688 |
A |
0.36 |
54 |
844 |
A |
851 |
K |
0.35 |
55 |
840 |
R |
846 |
G |
0.35 |
56 |
677 |
S |
695 |
K |
0.35 |
57 |
830 |
L |
835 |
L |
0.35 |
58 |
673 |
T |
681 |
E |
0.35 |
59 |
803 |
A |
809 |
P |
0.35 |
60 |
685 |
E |
691 |
R |
0.35 |
61 |
832 |
T |
836 |
E |
0.35 |
62 |
846 |
G |
854 |
Q |
0.35 |
63 |
693 |
G |
699 |
G |
0.35 |
64 |
670 |
A |
674 |
R |
0.35 |
65 |
692 |
Q |
696 |
K |
0.35 |
66 |
684 |
Q |
690 |
A |
0.35 |
67 |
702 |
L |
709 |
Q |
0.35 |
68 |
691 |
R |
696 |
K |
0.34 |
69 |
841 |
V |
845 |
Q |
0.34 |
70 |
804 |
P |
810 |
P |
0.34 |
71 |
680 |
Q |
690 |
A |
0.34 |
72 |
690 |
A |
694 |
R |
0.34 |
73 |
697 |
P |
703 |
A |
0.34 |
74 |
692 |
Q |
698 |
A |
0.34 |
75 |
834 |
H |
838 |
L |
0.34 |
76 |
679 |
R |
684 |
Q |
0.34 |
77 |
674 |
R |
679 |
R |
0.34 |
78 |
681 |
E |
686 |
A |
0.34 |
79 |
690 |
A |
698 |
A |
0.34 |
80 |
676 |
G |
681 |
E |
0.34 |
81 |
789 |
P |
793 |
L |
0.34 |
82 |
835 |
L |
840 |
R |
0.34 |
83 |
692 |
Q |
697 |
P |
0.34 |
84 |
687 |
A |
699 |
G |
0.34 |
85 |
691 |
R |
698 |
A |
0.33 |
86 |
798 |
G |
802 |
P |
0.33 |
87 |
843 |
S |
855 |
A |
0.33 |
88 |
839 |
Q |
843 |
S |
0.33 |
89 |
667 |
Q |
671 |
T |
0.33 |
90 |
683 |
G |
689 |
P |
0.33 |
91 |
675 |
T |
684 |
Q |
0.33 |
92 |
817 |
Q |
823 |
R |
0.33 |
93 |
734 |
V |
738 |
A |
0.33 |
94 |
839 |
Q |
855 |
A |
0.33 |
95 |
731 |
A |
735 |
E |
0.33 |
96 |
678 |
Q |
682 |
G |
0.32 |
97 |
686 |
A |
690 |
A |
0.32 |
98 |
676 |
G |
686 |
A |
0.32 |
99 |
811 |
T |
815 |
T |
0.32 |
100 |
711 |
S |
715 |
G |
0.32 |
101 |
674 |
R |
681 |
E |
0.32 |
102 |
694 |
R |
702 |
L |
0.32 |
103 |
674 |
R |
680 |
Q |
0.32 |
104 |
788 |
R |
794 |
G |
0.32 |
105 |
667 |
Q |
674 |
R |
0.32 |
106 |
787 |
P |
791 |
A |
0.32 |
107 |
668 |
G |
681 |
E |
0.32 |
108 |
683 |
G |
690 |
A |
0.32 |
109 |
816 |
E |
823 |
R |
0.32 |
110 |
845 |
Q |
853 |
Q |
0.32 |
111 |
786 |
A |
790 |
R |
0.32 |
112 |
806 |
Q |
812 |
P |
0.32 |
113 |
838 |
L |
843 |
S |
0.32 |
114 |
839 |
Q |
845 |
Q |
0.32 |
115 |
673 |
T |
682 |
G |
0.32 |
116 |
668 |
G |
672 |
S |
0.32 |
117 |
849 |
A |
855 |
A |
0.32 |
118 |
690 |
A |
695 |
K |
0.32 |
119 |
810 |
P |
818 |
P |
0.32 |
120 |
839 |
Q |
848 |
P |
0.32 |
121 |
810 |
P |
814 |
Q |
0.31 |
122 |
718 |
E |
723 |
Q |
0.31 |
123 |
678 |
Q |
684 |
Q |
0.31 |
124 |
830 |
L |
836 |
E |
0.31 |
125 |
688 |
A |
696 |
K |
0.31 |
126 |
673 |
T |
680 |
Q |
0.31 |
127 |
827 |
Q |
833 |
L |
0.31 |
128 |
837 |
R |
841 |
V |
0.31 |
129 |
834 |
H |
840 |
R |
0.31 |
130 |
683 |
G |
687 |
A |
0.31 |
131 |
699 |
G |
705 |
E |
0.31 |
132 |
676 |
G |
680 |
Q |
0.31 |
133 |
830 |
L |
834 |
H |
0.31 |
134 |
672 |
S |
682 |
G |
0.31 |
135 |
804 |
P |
808 |
V |
0.31 |
136 |
671 |
T |
679 |
R |
0.30 |
137 |
673 |
T |
677 |
S |
0.30 |
138 |
672 |
S |
686 |
A |
0.30 |
139 |
680 |
Q |
692 |
Q |
0.30 |
140 |
799 |
T |
804 |
P |
0.30 |
141 |
688 |
A |
703 |
A |
0.30 |
142 |
688 |
A |
692 |
Q |
0.30 |
143 |
839 |
Q |
846 |
G |
0.30 |
144 |
847 |
Q |
855 |
A |
0.30 |
145 |
841 |
V |
847 |
Q |
0.30 |
146 |
675 |
T |
681 |
E |
0.30 |
147 |
810 |
P |
820 |
R |
0.30 |
148 |
670 |
A |
675 |
T |
0.30 |
149 |
812 |
P |
818 |
P |
0.30 |
150 |
827 |
Q |
831 |
R |
0.30 |
151 |
669 |
P |
674 |
R |
0.30 |
152 |
832 |
T |
838 |
L |
0.30 |
153 |
797 |
A |
802 |
P |
0.30 |
154 |
807 |
P |
812 |
P |
0.30 |
155 |
800 |
G |
806 |
Q |
0.30 |
156 |
837 |
R |
845 |
Q |
0.30 |
157 |
806 |
Q |
810 |
P |
0.29 |
158 |
807 |
P |
811 |
T |
0.29 |
159 |
845 |
Q |
850 |
S |
0.29 |
160 |
679 |
R |
686 |
A |
0.29 |
161 |
810 |
P |
816 |
E |
0.29 |
162 |
671 |
T |
675 |
T |
0.29 |
163 |
672 |
S |
676 |
G |
0.29 |
164 |
682 |
G |
694 |
R |
0.29 |
165 |
679 |
R |
695 |
K |
0.29 |
166 |
835 |
L |
839 |
Q |
0.29 |
167 |
844 |
A |
850 |
S |
0.29 |
168 |
672 |
S |
680 |
Q |
0.29 |
169 |
717 |
P |
721 |
E |
0.29 |
170 |
847 |
Q |
853 |
Q |
0.29 |
171 |
802 |
P |
809 |
P |
0.29 |
172 |
689 |
P |
697 |
P |
0.29 |
173 |
699 |
G |
703 |
A |
0.29 |
174 |
830 |
L |
841 |
V |
0.29 |
175 |
670 |
A |
680 |
Q |
0.29 |
176 |
696 |
K |
700 |
K |
0.29 |
177 |
679 |
R |
690 |
A |
0.29 |
178 |
675 |
T |
679 |
R |
0.29 |
179 |
833 |
L |
839 |
Q |
0.29 |
180 |
696 |
K |
703 |
A |
0.29 |
181 |
685 |
E |
697 |
P |
0.29 |
182 |
796 |
P |
802 |
P |
0.29 |
183 |
690 |
A |
696 |
K |
0.29 |
184 |
833 |
L |
837 |
R |
0.28 |
185 |
843 |
S |
848 |
P |
0.28 |
186 |
686 |
A |
694 |
R |
0.28 |
187 |
680 |
Q |
686 |
A |
0.28 |
188 |
674 |
R |
685 |
E |
0.28 |
189 |
835 |
L |
847 |
Q |
0.28 |
190 |
801 |
G |
811 |
T |
0.28 |
191 |
745 |
E |
760 |
Q |
0.28 |
192 |
704 |
S |
709 |
Q |
0.28 |
193 |
691 |
R |
702 |
L |
0.28 |
194 |
833 |
L |
841 |
V |
0.28 |
195 |
842 |
R |
850 |
S |
0.28 |
196 |
723 |
Q |
727 |
D |
0.28 |
197 |
838 |
L |
846 |
G |
0.28 |
198 |
790 |
R |
794 |
G |
0.28 |
199 |
702 |
L |
707 |
P |
0.28 |
200 |
836 |
E |
842 |
R |
0.28 |
201 |
684 |
Q |
691 |
R |
0.28 |
202 |
748 |
P |
756 |
L |
0.28 |
203 |
841 |
V |
848 |
P |
0.28 |
204 |
832 |
T |
837 |
R |
0.28 |
205 |
817 |
Q |
821 |
E |
0.28 |
206 |
670 |
A |
685 |
E |
0.28 |
207 |
702 |
L |
710 |
P |
0.28 |
208 |
667 |
Q |
677 |
S |
0.28 |
209 |
667 |
Q |
680 |
Q |
0.28 |
210 |
787 |
P |
794 |
G |
0.27 |
211 |
838 |
L |
844 |
A |
0.27 |
212 |
671 |
T |
680 |
Q |
0.27 |
213 |
667 |
Q |
681 |
E |
0.27 |
214 |
669 |
P |
683 |
G |
0.27 |
215 |
841 |
V |
850 |
S |
0.27 |
216 |
667 |
Q |
684 |
Q |
0.27 |
217 |
722 |
S |
726 |
V |
0.27 |
218 |
719 |
G |
724 |
D |
0.27 |
219 |
845 |
Q |
849 |
A |
0.27 |
220 |
834 |
H |
842 |
R |
0.27 |
221 |
685 |
E |
693 |
G |
0.27 |
222 |
812 |
P |
821 |
E |
0.27 |
223 |
840 |
R |
850 |
S |
0.27 |
224 |
697 |
P |
702 |
L |
0.27 |
225 |
830 |
L |
837 |
R |
0.27 |
226 |
746 |
F |
754 |
D |
0.27 |
227 |
672 |
S |
693 |
G |
0.27 |
228 |
687 |
A |
694 |
R |
0.27 |
229 |
675 |
T |
688 |
A |
0.27 |
230 |
687 |
A |
703 |
A |
0.27 |
231 |
687 |
A |
702 |
L |
0.27 |
232 |
844 |
A |
855 |
A |
0.27 |
233 |
752 |
S |
775 |
G |
0.27 |
234 |
689 |
P |
694 |
R |
0.27 |
235 |
747 |
P |
751 |
N |
0.27 |
236 |
681 |
E |
695 |
K |
0.27 |
237 |
842 |
R |
849 |
A |
0.27 |
238 |
770 |
D |
774 |
E |
0.27 |
239 |
677 |
S |
689 |
P |
0.27 |
240 |
667 |
Q |
685 |
E |
0.27 |
241 |
803 |
A |
808 |
V |
0.27 |
242 |
844 |
A |
852 |
E |
0.26 |
243 |
676 |
G |
685 |
E |
0.26 |
244 |
676 |
G |
684 |
Q |
0.26 |
245 |
759 |
H |
771 |
S |
0.26 |
246 |
831 |
R |
837 |
R |
0.26 |
247 |
835 |
L |
841 |
V |
0.26 |
248 |
669 |
P |
675 |
T |
0.26 |
249 |
799 |
T |
803 |
A |
0.26 |
250 |
835 |
L |
853 |
Q |
0.26 |
251 |
799 |
T |
805 |
L |
0.26 |
252 |
683 |
G |
701 |
S |
0.26 |
253 |
719 |
G |
723 |
Q |
0.26 |
254 |
845 |
Q |
855 |
A |
0.26 |
255 |
681 |
E |
689 |
P |
0.26 |
256 |
677 |
S |
688 |
A |
0.26 |
257 |
840 |
R |
847 |
Q |
0.26 |
258 |
675 |
T |
685 |
E |
0.26 |
259 |
831 |
R |
836 |
E |
0.26 |
260 |
800 |
G |
804 |
P |
0.26 |
261 |
692 |
Q |
702 |
L |
0.26 |
262 |
832 |
T |
840 |
R |
0.26 |
263 |
848 |
P |
852 |
E |
0.26 |
264 |
670 |
A |
676 |
G |
0.26 |
265 |
679 |
R |
688 |
A |
0.26 |
266 |
682 |
G |
689 |
P |
0.26 |
267 |
686 |
A |
695 |
K |
0.26 |
268 |
687 |
A |
695 |
K |
0.26 |
269 |
844 |
A |
849 |
A |
0.26 |
270 |
677 |
S |
685 |
E |
0.26 |
271 |
697 |
P |
705 |
E |
0.26 |
272 |
677 |
S |
683 |
G |
0.26 |
273 |
679 |
R |
689 |
P |
0.26 |
274 |
836 |
E |
840 |
R |
0.26 |
275 |
693 |
G |
701 |
S |
0.26 |
276 |
838 |
L |
849 |
A |
0.26 |
277 |
675 |
T |
695 |
K |
0.26 |
278 |
680 |
Q |
688 |
A |
0.26 |
279 |
685 |
E |
689 |
P |
0.26 |
280 |
683 |
G |
688 |
A |
0.25 |
281 |
840 |
R |
852 |
E |
0.25 |
282 |
687 |
A |
696 |
K |
0.25 |
283 |
688 |
A |
693 |
G |
0.25 |
284 |
668 |
G |
678 |
Q |
0.25 |
285 |
832 |
T |
852 |
E |
0.25 |
286 |
689 |
P |
695 |
K |
0.25 |
287 |
671 |
T |
687 |
A |
0.25 |
288 |
668 |
G |
675 |
T |
0.25 |
289 |
693 |
G |
698 |
A |
0.25 |
290 |
775 |
G |
779 |
F |
0.25 |
291 |
809 |
P |
822 |
Q |
0.25 |
292 |
688 |
A |
695 |
K |
0.25 |
293 |
687 |
A |
698 |
A |
0.25 |
294 |
683 |
G |
691 |
R |
0.25 |
295 |
670 |
A |
692 |
Q |
0.25 |
296 |
674 |
R |
692 |
Q |
0.25 |
297 |
722 |
S |
727 |
D |
0.25 |
298 |
668 |
G |
677 |
S |
0.25 |
299 |
691 |
R |
699 |
G |
0.25 |
300 |
668 |
G |
685 |
E |
0.25 |
301 |
669 |
P |
682 |
G |
0.25 |
302 |
695 |
K |
703 |
A |
0.25 |
303 |
684 |
Q |
696 |
K |
0.25 |
304 |
843 |
S |
849 |
A |
0.25 |
305 |
671 |
T |
681 |
E |
0.25 |
306 |
682 |
G |
687 |
A |
0.25 |
307 |
751 |
N |
758 |
V |
0.25 |
Alignment robustness analysis
First most common residue correlation
Second most common residue correlation